Georges Bastin - Quantitative analysis of metabolic networks and design of minimal bioreaction models

arima:1891 - Revue Africaine de la Recherche en Informatique et Mathématiques Appliquées, August 15, 2008, Volume 9, 2007 Conference in Honor of Claude Lobry, 2008 - https://doi.org/10.46298/arima.1891
Quantitative analysis of metabolic networks and design of minimal bioreaction models

Authors: Georges Bastin

This tutorial paper is concerned with the design of macroscopic bioreaction models on the basis a quantitative analysis of the underlying cell metabolism. The paper starts with a review of two fundamental algebraic techniques for the quantitative analysis of metabolic networks : (i) the decomposition of complex metabolic networks into elementary pathways (or elementary modes), (ii) the metabolic flux analysis which aims at computing the entire intracellular flux distribution from a limited number of flux meaurements. Then it is discussed how these two fundamental techniques can be exploited to design minimal bioreaction models by using a systematic model reduction approach that automatically produces a family of equivalent minimal models which are fully compatible with the underlying metabolism and consistent with the available experimental data. The theory is illustrated with an experimental case-study on CHO cells.


Volume: Volume 9, 2007 Conference in Honor of Claude Lobry, 2008
Published on: August 15, 2008
Submitted on: February 1, 2008
Keywords: Model reduction, Metabolic networks, Metabolic flux analysis,Analyse des flux métaboliques,Bioréactions,Réseaux métaboliques,Réduction de modèle,[INFO] Computer Science [cs],[MATH] Mathematics [math]


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