arima:1493 -
Revue Africaine de Recherche en Informatique et Mathématiques Appliquées,
December 27, 2016,
Volume 23 - 2016 - Special issue for LEM2I 2016
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https://doi.org/10.46298/arima.1493
A chemotherapeutic treatment model for cell population with resistant tumor is considered. We consider the case of two drugs one with pulsed effect and the other one with continuous effect. We investigate stability of the trivial periodic solutions and the onset of nontrivial periodic solutions by the mean of Lyapunov-Schmidt bifurcation.